17^th International Conference on Dermatology and Cosmetic Medicine August 08-09, 2022 Zurich, Switzerland

Biography:

Nino Nishnianidze Graduated Tbilisi Classic and Traditional Medicine Academy, Faculty of Medicine, diploma of Doctor of General practice. She passed the complete the whole course of aesthetic cosmetology, acupuncture (Moscow), passed the complete course of plastic and aesthetic dermato-cosmetology, and also the complete residency courses in dermato-venerogy. She attends seminars and master classes in dermatology, dermato–pathology, dermatooncology and dermato-surgery. She is the member of Georgian Association of Dermatology and Venereology, Georgian Society of Aesthetic Medicine, Georgian Association of Photodermatology and Skin Cancer.

Abstract:

Biography:

Nino Kokhreidze is affiliated to Tbilisi Classic and Traditional Medicine Academy, Republic of Georgia.

Abstract:

Subject: Acne is rather common problem of fatty gland, inflammation, caused by the pathological process, based on numerous factors; whereby different type rash develops on the skin, such as comedone, papulapustules, and/or nodular-cystic type. Such forms of acne often leave scars and spots on the skin (atrophic or hypertrophic). There are different cosmetic methods (ultrasonic, microwave, IPL- methods, etc.) to solve these problems, but they cannot be fully cleared. Through dermabrasion and chemical peeling methods the problem of spots and scars is solved. Goal: By small-invasive methods (By microdermabrasion methods and various chemical acids) to get the effect on solution of the above existing problems. Material and methods: I divided patients into 2 groups. Group 1 included 32 patients with post-acne scars (Hypotrophic form), out of which 16 female and 7 male of 24 to 36 years of age. Scars were 1-8 years old. Group 2 consisted of patients with post-acne spots. Their number wa1s 7 (15 females, 2 males), all the spots were relatively new, 4-12 months old. In the 1 Group the superficial anesthesia with the ointment was done, the skin was cleaned by chlorhexidine solution and each scar was treated by microcrystalline surface mounts (mount sizes ranging from 75 microns (In case of old and rough edges, if any) up to 125-150-170 microns (compared to new-soft scars). The procedure was repeated 4-6 times with 10 day intervals. The procedure can be repeated 6-12 months later. The skin exfoliation was done by the device and blood circulation was improved and tissues were enriched by oxygen, the restructuration of the damaged part was done. In the Group 2 the skin was treated with combined chemical acids (14% salicylic acid, 15% glycolic acid, 14% lactic acid, azelaic acid 2%, 8% citric acid.) The trichloracetic acid 15-25-35%, salicylic acid 30%, glycolic acid 50-70% may be used for evaluation of the spot condition. The procedure included 4 procedures with 12-14 day intervals. The procedure may be repeated 6-12 months later. The follow-up period included up to 3-14 months. Efficiency is based on long-term results. Results: After the procedure skin condition changed dramatically, its structure improved, the skin color became pale pink, porosity of the skin reduced, the collagen-elastin synthesis, skin layer regeneration, restructuration occurred through improvement of blood circulation and exfoliation. Outcome: The obtained results showed that the procedures, done by apparatus microdermabrasion and chemical peeling are very effective for further resolution of post-acne scars and spots.

Biography:

Abstract:

Aims: To compare the efficacy of various therapeutic modalities in treatment of mild and moderate acne scar according to the global acne scarring grading system. Methods: It was an interventional, non randomised control study. Total 90 patients were randomly divided into 6 groups of 15 patients each into the category of Grade 2 and 3 scars according to Goodman and Baron scale distributed into 3 modalities of Cross, Dermaroller and Co2 fractional. Profile of patients was recorded and objective & subjective evaluation along with assessment of patient satisfaction was done at the end of 1 year. Background: Acne, the most common skin malady, is a disorder of pilosebaceous units that peaks between the ages of 14 and the beginning of the third decade, but may persist into or develop de novo in adulthood (20% men and 35% women), affecting almost all ethnicities and races. If more extensive deep dermal damage occurs, broad scars can develop like, rolling scars or boxcar scars. There lies paucity in the data for treatment of Acne scars which significantly hampers the quality of life. The treatment modality of acne scars depends on different factors like early treatment, types of scars, infrastructure and financial status of the patient. Results: A total of 90 patients were enrolled in the study. Patients of age 18-35 years were enrolled in the study among which males were 44 and females were 46. Greater part of the patients belonged to icepick+rolling group which was 42% and all three types of scars were present in only 8% of patients. Icepick + boxcar were observed least only in 2%.In grade 2 and 3 scars, statistically significant improvement was observed in all modalities. However, in grade 2 scars, the improvement was similar across groups with respect to Quantitative (p=0.05) and qualitative grading (p=0.22). While in grade 3, the improvement was significantly different with respect to Quantitative (p<0.001) and qualitative grading (p<0.001). Post-hoc comparisons with Scheffe’s correction revealed that Cross had inferior efficacy with respect to Quantitative as well as qualitative grading as compared to dermaroller and CO2 laser. Conclusion: Cross can be a cheaper and feasible alternative to dermaroller and CO2 in grade 2 scars. However, dermaroller and/or CO2 should be considered for grade 3 scars depending on infrastructural limitations and patient’s choice.

Biography:

Sergey Suchkov graduated from Astrakhan State Medical University and awarded with MD, then in 1985 maintained his PhD at the I.M. Sechenov Moscow Medical Academy and in 2001, maintained his Doctorship Degree at the Nat Inst of Immunology, Russia. From 1987 through 1989, he was a senior Researcher, Koltzov Inst of Developmental Biology. From 1989 through 1995, he was a Head of the Lab of Clinical Immunology, Helmholtz Eye Research Institute in Moscow. From 1995 through 2004, a Chair of the Dept for Clinical Immunology, Moscow Clinical Research Institute (MONIKI. Dr Suchkov has been trained at: NIH; Wills Eye Hospital, PA, USA; Univ of Florida in Gainesville; UCSF, S-F, CA, USA; Johns Hopkins University, Baltimore, MD, USA. He was an Exe Secretary-in-Chief of the Editorial Board, Biomedical Science, an international journal published jointly by the USSR Academy of Sciences and the Royal Society of Chemistry, UK. At present, Dr Sergey Suchkov is a Scientific Director of The Institute for Global Health and Chair, Dept for Personalized Medicine & Precision Nutrition of the MGUPP, Moscow, Russia. He is a member of the: New York Academy of Sciences, USA; American Chemical Society (ACS), USA; American Heart Association (AHA), USA; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, EU; ARVO (American Association for Research in Vision and Ophthalmology); ISER (International Society for Eye Research); PMC (Personalized Medicine Coalition), Washington, USA.

Abstract:

Abs against myelin basic protein/MBP and cardiac myosin (CM) endowing with proteolytic activity (Abproteases with functionality) are of great value to monitor demyelination and/or autoimmune myocarditis (AIM) to illustrate the evolution of multiple sclerosis (MS) and myocardial autoimmunity conditions. Anti- MBP autoAbs from MS patients and patients with AIM exhibited specific proteolytic cleavage of MBP and CM, respectively, which, in turn, markedly differed between: (i) MS and AIM patients and healthy controls, on one hand; (ii) different clinical MS and/or AIM courses; (iii) EDSS scales of demyelination and cardiac autoimmunity scores to correlate with the disability of MS and/or AIM patients to predict the transformation prior to changes of the clinical courses. Ab-mediated proteolysis of MBP and CM was shown to be sequence-specific whilst demonstrating, for instance, in MBP case five sites of preferential proteolysis to be located within the immunodominant regions of MBP and to fall inside into 5 sequences fixed. Some of the latter (with the highest encephalitogenic properties) were proved to act as a specific inducer of EAE and to be attacked by the MBP-targeted Ab-proteases in MS patients with the most severe (progradient) clinical courses. The other ones whilst being less immunogenic happened to be EAE inducers very rare but were shown to be attacked by Ab-proteases in MS patients with moderate (remission-type) clinical courses. The activity of MBP- and CM-targeted Ab-proteases was first registered at the subclinical stages 1-2 years prior to the clinical illness of both MS and AIM. About 24% of the direct MS-related relatives and 26% of AIM-related ones were seropositive for low-active Ab-proteases from which 22-28% of the seropositive relatives established were being monitored for 2 years whilst demonstrating a stable growth of the Ab-associated proteolytic activity. Moreover, some of the low-active Ab-proteases in persons at MS- and/or AIM-related risks (at the subclinical stages), and primary clinical and MRT manifestations observed were coincided with the activity to have its midlevel reached. Registration in the evolution of highly immunogenic Ab-proteases would illustrate either risks of transformation of subclinical stages into clinical ones, or risks of exacerbations to develop. The activity of Ab-proteases in combination with the sequence-specificity would confirm a high subclinical and predictive (translational) value of the tools as applicable for personalized monitoring protocols. Ab-proteases can be programmed and re-programmed to suit the needs of the body metabolism or could be designed for the development of principally new catalysts with no natural counterparts. Further studies on targeted Ab-mediated proteolysis may provide a translational tool for predicting demyelination and myocardial autoimmunity conditions and thus the disability of the MS and/or AIM patients.

Biography:

Dr. Gor Amirbekyan – Plastic & Micro Surgeon, M.D., Ph.D.; Head of Plastic & Micro Surgery Service at NEW-MED Clinic; Assistant Lecturer of the Department of Plastic Surgery at Yerevan State Medical University after Mkhitar Heratsi (YSMU).

Abstract:

One of the types of ethnic noses are Armenian noses, most of which are described to have thick skin and subdermal fat tissue, big hump, wide alar cartilages, with long lateral wings and because of that we have lower location of the tip of the nose. In 95% of the cases, patients also have deviated septum with hypertrophy of lower nasal turbinate, in about 38% of cases patients also have deviation of nasal pyramid, which is result of trauma. During the rhinoplasty we have to solve several problems with 1. Resection of deviated part of the septum, leaving straightened L-shaped cartilage with at least 8-10 mm wide 2. Vasotomy/resection of lower nasal turbinate (depending on the size and consistency) 3. Removal of subdermal fat tissue 4. Reduction of hump, lateral osteotomy (sometimes in 2 level) 5. Correction of inner nasal valve (spreader flaps or grafts) 6. Formation of the tip of the nose (cephalic resection of lateral wings of alar cartilages, sliding of lateral wings of alar cartilages, formation of the new dome with hemitransdomal suture, very random resection of medial wings of alar cartilages, shield graft) 7. Fixation of the tip in the needed position (tongue in groove, septum extension graft, columella strut graft (very rarely)) For the period of January 2021 - April 2021 257 primary rhinoplasties were performed by our team. 68 (26,5%) patients were male and 189 (73,5%) were female. The age of the patients was as following 20-30 years old 135 patients (52,5%), 30-40 years old 78 patients (30,4%), 40-50 years old 36 patients (14%) and 8 patients (3,1%) were over 50 years. 230 (89,5%) patients had big hump, 244 (94,9%) patients had deviated septum and hypertrophy of lower turbinate, 169 (65,8%) patients had long lateral wings and lower location of the tip of the nose, 102 (39,7%) patients had thick skin and subdermal fat tissue. In all cases osteotomies were done with piezotome, on all patients correction of inner valve was done by spreader flaps, subdermal fat tissue had been removed in all patients who have thick subdermal fat tissue. Resection of cephalic edges of lateral wings of alar cartilages were performed in all cases, and also to fix the position of the tip and to fix the nasolabial angle in all cases tongue in groove had been performed. Hemitransdomal suture for the fixation of the dome in all cases. Sliding of lateral wings of alar cartilages were done on all patients who had long lateral wings. Primary intentional healing of wounds had been seen on all patients, subdermal thick scaring had been seen on 50 (19,5 %) patients. Injections of kenalog were performed in these cases, and in 43 cases this procedure was effective, and in 7 cases revision tip correction was done: thick scar tissue had been removed, and in all patients we had no more complications. Tip rotation controller suture was performed in 28(10,9%) cases. Late bleeding was observed on 2 patients, whom conchotomy had been done during the operation. So the bases for best result in ethnic Armenian noses are.
1. Removal of hump with rasp for better control of the amount of removing bone and cartilage
2. osteotomy with piezotome, which helps to have better control of the bone cutting line and is less traumatic for bone tissue,
3. Correction of the inner valve with spreader flaps is quicker and valve is more elastic
4. In order to prevent further hanging of the tip, tongue in groove is more reliable method than the others.
5. To have neat tip resection of cephalic edge of lateral wings has to be done, leaving about 5-7 mm of cartilage depending of the thickness of the skin, size of the forthcoming nose and the sex of the patient.
6. Sliding of the lateral wings of alar cartilages is better choice than the resection of lateral wings. This way the strength of the lateral wings is more and, the chance to have problem with outer valve is less.
7. Hemitransdomal fixation sutures is a must, to have neat, narrow and straight tip.
8. Tip rotation controller sutures is technique of choice, if we have week medial wings of alar cartilages, and if during the operation the surgeon sees the risk of bending of medial wings.

Biography:

Deanna Mulvihill has her expertise in evaluation and passion in improving the health and wellbeing. Her open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. She has built this model after years of experience in research, evaluation, teaching and administration both in hospital and education institutions. The foundation is based on fourth generation evaluation (Guba& Lincoln, 1989) which is a methodology that utilizes the previous generations of evaluation: measurement, description and judgment. It allows for value-pluralism. This approach is responsive to all stakeholders and has a different way of focusing.

Abstract:

Introduction: Diaphragmatic Dysfunction is a common cause of failed extubation and prolonged mechanical ventilation after pediatric cardiac surgery in up to 14%. This study aims to evaluate the role of critical care bedside Ultrasound performed by intensivist to diagnose diaphragmatic dysfunction and the need for plication after pediatric cardiac surgery. Methods: Retrospective cohort study on prospectively collected data for post-operative children admitted to PCICU during 2015. Diaphragmatic dysfunction was suspected based on difficulties in weaning from positive pressure ventilation or Chest X-Ray findings. Ultrasound studies were performed by PCICU intensivist and confirmed by qualified radiologist. Results: Out of 344 post-operative patients, 32 needed diaphragm ultrasound for suspected dysfunction. Ultrasound confirmed diaphragmatic dysfunction in17/32 (53%) patients with an average age and weight of (10.8±3.8) months and (6±1) Kg respectively. The incidence rate of diaphragmatic dysfunction was (4.9%) in relation to the whole population. Diaphragmatic plication was needed in 9/17 cases (53%), with rate of 2.6% in post-operative cardiac children. Mean plication day was (15.1±1.3) after surgery. All patients who underwent plication were under 4 months of age. Post plication they were discharged with mean Pediatric CICU and hospital stay of (19±3.5) and (42±8) days respectively. Conclusions: Critical care ultrasound assessment of diaphragmatic movement is a useful and practical bedside tool that can be performed by a trained pediatric (CICU) intensivist. It may help in early detection and management of diaphragmatic dysfunction post pediatric cardiac surgery which may have potential positive effect on morbidity and outcome.
Recent Publications:
1. Ultrasound guided post-pyloric feeding tube insertion in peri-operative cardiac infants. Hamadah HK et al (2021). Cardiology in the Young. 2021 Oct 14:1-4.
2. Surgical outcome of Yasui procedure for preserving biventricular function: single centre experience. Alhadi O, Kabbani MS, Alhabshan F, Alamer M, Alomrani A, Hamadah H. Cardiol Young. 2021 Nov 15:1-5.
3. Outcome of truncus arteriosus repair: 20 years of single-center experience comparing early versus late surgical repair. Hrfi A, Ismail M, Mohammed MHA, Hamadah HK, Alhabshan F, Abu-Sulaiman R, Kabbani MS. Cardiol Young. 2021 Oct 20:1-7.
4. Aortopulmonary window: Types, associated cardiovascular anomalies, and surgical outcome. Retrospective analysis of a single center experience. Bin-Moallim Mohammed, Hussam K. Hamadah, et al. Saudi Heart Assoc. 2020 May 10;32(2):127-133.
5. Predictors of Reopening the Sternum in Children After Cardiac Surgery. Ghassan A. Shaath,1; Abdulraouf M. Z. Jijeh,1; Sameh R. Ismail,1; Omar Hijazi,1; Riyadh Abu Sulaiman, 1,2; Wedad Almadani, 2; Mohammed Husam Hamadah,1; Hani K. Najm, 1; Mohamed S. Kabbani, Pediatr Crit Care Med. 2020 Mar;21(3):235-239.

Biography:

Dr Mukesh Gabhane has completed his graduation in Bachelor of Medicine and Bachelor of Surgery (MBBS) from the Maharashtra University of Health Sciences (MUHS), Nashik, followed by MBA (pharmaceuticals) from Narsee Monjee Institute of Management Studies, Mumbai. He has experience of over a decade working in medical affairs (medico-marketing, pharmacovigilance and clinical studies).

Abstract:

Purpose: Chronic spontaneous/idiopathic urticaria (CSU/CIU) impairs quality of life and affects performance at work/school. Second-generation H1-antihistamines are recommended as first-line treatment for CSU. Updosing (upto 4 times) is recommended in patients unresponsive to the standard dose. This study evaluated efficacy and safety of desloratadine 10mg in the treatment of CSU. Methodology: A multi-centric, open-label, single-arm, phase 3 study was conducted in India in adult patients with moderate-to-severe CSU, active CSU ≥3 weeks, wheals present for ≥3 days/week and not responding to ≥2 weeks of desloratadine 5mg . Desloratadine 10mg was administered orally once daily for 4 weeks. Study assessments included weekly Urticaria Activity Score (UAS7) and Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL). Results: Total 256 patients (mean age: 35.3 years) were enrolled in the study. Desloratadine 10mg led to a significant improvement as early as at week 2. Significant improvement by 42.32% (p<0.0001) was seen in mean UAS7 at week 4 (18.17) compared to baseline (31.90). The mean CU-Q2oL score improved by 38.48% from baseline (59.81) to week 4 (35.36) (p<0.0001). By week 4, 21% of patients improved to mild urticaria (UAS7=7-15) and 10% of patients were either well controlled or urticaria free (UAS7=0-6). Adverse events reported in 5.5% of patients were mostly mild (80%), non-serious and did not lead to discontinuation. Two events (0.8%) of dry mouth were reported. Somnolence/ drowsiness was not reported in this study. Conclusion: Desloratadine 10mg once daily was efficacious and well tolerated in patients with moderate-to-severe CSU nonresponsive to standard dose desloratadine. (Study registration number: CTRI/2017/10/010146)

Biography:

Niraj Khatri Sapkota has completed his PhD in Molecular Physiology applications to Cardiovascular Pharmacology at the age of 32 years from Zhejiang University, China, World top 70th academically ranked University in 2019, as well one of the Thomson Reuters and Elsevier best ranked university of the world, he is now working as an Associate Professor in the Department of Physiology in Chitwan Medical College affiliated to Tribhuvan University, Nepal. Expertise subjects Physiology and Pharmacology solving problem on research oriented case study. He is also an organizing committee member of international conference in cardiovascular research and clinical cardiology Valencia, Spain 2020, and presented his paper in international conference in London, UK in 2017 and has even published clinical case report in PubMed indexed Journal along with, is a writer of the review book, is also in Author Aid.

Abstract:

Case Report: Patient of age 20 years old visited medicine OPD complaining of dyspnoea and dysphagia, diaphoresis with sign of, tachypnea (21 breathe per minute)and tachycardia of 150 btm with blood pressure 90/60 mm of Hg, he has history of 12 years pneumonia repeated treatment with recent diagnosis of tuberculosis, treated by antituberculosis medication before 6 months, his weight was 25 kg at the moment of visit, in his previous visit to different clinician, suspected to have cancer due to his reduced weight indication, due to dyspnoea symptoms, prescribed asthmatic medication which he undergone for 15 days for example salmeterol, ipratropium, emsolone, fluticasone before the visit to our OPD, during this course of medication his shortness of breath exacerbated and along with difficulty in swallowing hence he forced to come to visit us. During our OPD visit of his examination - He was suspected to suffer from multiple organ problem due to demonstrated symptomatic status like as tachycardia (heartbeat of 150), dyspnoea, dysphagia (unable to swallow) and more focused symptom was critical reduction in weight 25 kg in 10 years of time, hence he was referred to Cardiology department, for further examination expecting that there must be involved of cardiac problem if not we will rule out it. On visit to cardiology department, Echo test was said to perform, not performed till his this age of 20 years, before visit to us. Test performed for the diagnosis in our Hospital, Blood test, LFT, ECG, ECHO. Test Result: Upon admission at our institution, Chitwan Medical College Teaching 1, Nepal. He denied angina or recent heart failure symptoms. He underwent transthoracic echocardiography that revealed an EF of 36% with severe global left ventricular (LV) hypokinesia. His echo impression revealed Global LV hypokinesia. On the basis of echo test result he was prescribed spironolactone, metoprolol,and one antibiotic to prevent from infection improve and strengthens the muscle of heart so that his prognosis of symptoms be amended in assumption to remodel the cardiac system and to enhance easier life survivality. Conclusion: This is clear undiagnosed case of long term pneumonia treared Global left ventricular hypokinesia, Discussion: Sometime physician and clinician only concentrate on the symptomatic feature focussed to that organ problem, and they get confused on the exact organ failure or association of the concerned part that leds to undiagnosed the case and finally worst outcome, finally death. Diagnosed diabetes by Debix, a proprietary Ayurvedic or in alternative medicine manufactured by Sandu pharmaceutical Pvt.Ltd without any report of side effects under continuous supervision, at least for four months to fully manage the case.
Recent Publications :
1. Sapkota NK (2017). Effect of phototherapy in ionized Magnesium and bilirubin level in hyperbilirubinmic neonates. Innovare Journal of Medical Sciences. 5(1):10-11.
2. Sapkota NK (2017).Pre-hypertension independent deleterious effect in body system. Innovare journal of Medical Sciences. 2(4):1-2.
3. Sapkota NK, Swain KC (2017). Obesity, type 2 Diabetes mellitus and its management. Innovare Journal of Health Sciences. 5(1):17-20.
4. Ram Lochan Yadav, Khadka R , Agrawal K, Thakur D, Sharma D, Shah DK, Yadav PK, Sapkota NK, et al(2016). Analysis of cardiac autonomic modulation in normotensive obese and eutrophic adults of Nepal. International journal of research in Medical Sciences.4 (1):105-110.
5. Sharma D, Paudel BH, Khadka R, Thakur D , Sapkota NK et al (2015). Time domain and frequency domain analysis of heart rate variability in elite Nepalese football players. International Journal of Biomedical Research.6(09): 641-646